South Carolina currently maintains strict laws regarding cannabis, with both recreational and medical use remaining illegal at the state level. The only exception permits the use of low-THC CBD oil for qualifying patients with severe epilepsy, a provision established by Julian's Law in 2014.

Due to this legal landscape, there are no state-licensed cannabis home delivery businesses or related licenses available for sale in South Carolina. While discussions around cannabis reform are ongoing, most notably with the South Carolina Compassionate Care Act, attempts to establish a comprehensive medical cannabis program have passed the Senate but consistently stalled in the House of Representatives.